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Expanding molecular diversity of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products by radical S-adenosylmethionine (SAM) enzymes: recent advances and mechanistic insights
Feng Jiawei, Mo Jiarong, Hemu Xinya
2025, 23(3): 257-268. DOI: 10.1016/S1875-5364(25)60845-4
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The prospect and underlying mechanisms of Chinese medicine in treating periodontitis
Xing Aili, Wang Feng, Liu Jinzhong, Zhang Yuan, He Jingya, Zhao Bin, Sun Bin
2025, 23(3): 269-285. DOI: 10.1016/S1875-5364(25)60842-9
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Recent advances in regulating the cell cycle through inhibiting CDKs for cancer treatment
Chen Weijiao, Zhuang Xujie, Chen Yuanyuan, Yang Huanaoyu, Shen Linhu, Feng Sikai, Min Wenjian, Yuan Kai, Yang Peng
2025, 23(3): 286-298. DOI: 10.1016/S1875-5364(25)60846-6
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Saponins from Aralia taibaiensis protect against brain ischemia/reperfusion injuries by regulating the apelin/AMPK pathway
Li Zhengrong, Liu Yuwen, Liu Kedi, Tao Xingru, Hu Naping, Li Wangting, Duan Jialin
2025, 23(3): 299-310. DOI: 10.1016/S1875-5364(25)60841-7
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Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-β-tubulin mediated synergistic mechanism of "mitophagy-unfolded protein response" and mitophagy
Chang Xing, Zhou Siyuan, Huang Yu, Liu Jinfeng, Wang Yanli, Guan Xuanke, Wu Qiaomin, Liu Zhiming, Liu Ruxiu
2025, 23(3): 311-321. DOI: 10.1016/S1875-5364(25)60838-7
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NUMB endocytic adaptor protein (NUMB) mediates the anti-hepatic fibrosis effect of artesunate (ART) by inducing senescence in hepatic stellate cells (HSCs)
Qiu Yangling, Li Yujia, Li Mengran, Wang Yingqian, Shen Min, Shao Jiangjuan, Zhang Feng, Xu Xuefen, Wang Feixia, Zhang Zili, Zheng Shizhong
2025, 23(3): 322-333. DOI: 10.1016/S1875-5364(25)60836-3
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Magnolol inhibits appetite and causes visceral fat loss through Growth/differentiation factor-15 (GDF-15) by activating transcription factor 4-CCAAT enhancer binding protein γ-mediated endoplasmic reticulum stress responses
Cheng Keru, Zhou Yanyun, Hao Yilong, Wu Shengyun, Wang Nanping, Zhang Peng, Wang Yinfang
2025, 23(3): 334-345. DOI: 10.1016/S1875-5364(25)60835-1
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Ustusolate E and 11α-Hydroxy-Ustusolate E induce apoptosis in cancer cell lines by regulating the PI3K/AKT/mTOR and p-53 pathways
Rehmutulla Mewlude, Zhang Sitian, Yin Jie, Huang Jianzheng, Xiao Yang, Hu Zhengxi, Tong Qingyi, Zhang Yonghui
2025, 23(3): 346-353. DOI: 10.1016/S1875-5364(25)60840-5
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Ziyuglycoside II suppressed the progression of osteosarcoma by coordinating estrogen-related receptor gamma and p53 signaling pathway
Du Hang, Wu Dongjin, Zhang Tianyu, Zhong Ying, Wu Kaiyi, Guo Xin, Sheng Lisong, Huang Nana, Gao Chunzheng, Sun Rong
2025, 23(3): 354-367. DOI: 10.1016/S1875-5364(25)60847-8
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Discovery of fernane-type triterpenoids from Diaporthe discoidispora using genome mining and HSQC-based SMART technology
Wang Yajing, Li Yongfu, Dong Yan, Yu Chunyan, Liu Chengwei, Li Chang, Sun Yi, Pei Yuehu
2025, 23(3): 368-376. DOI: 10.1016/S1875-5364(25)60837-5
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New acylphloroglucinol-sesquiterpenoid adducts with antiviral activities from Dryopteris atrata
Zhang Jihui, Wang Jinghao, Tang Wei, Shen Xi, Chen Jinlin, Ou Huilin, Situ Qianyi, Li Yaolan, Wang Guocai, Zhang Yubo, Chen Nenghua
2025, 23(3): 377-384. DOI: 10.1016/S1875-5364(25)60839-9
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