ZHOU Yu-Hong, ZHANG Shui-Ying, GUO Qiang, CHAI Xing-Yun, JIANG Yong, TU Peng-Fei. Chemical investigation of the roots of Polygala sibirica L.[J]. Chinese Journal of Natural Medicines, 2014, 12(3): 225-228.
Citation: ZHOU Yu-Hong, ZHANG Shui-Ying, GUO Qiang, CHAI Xing-Yun, JIANG Yong, TU Peng-Fei. Chemical investigation of the roots of Polygala sibirica L.[J]. Chinese Journal of Natural Medicines, 2014, 12(3): 225-228.

Chemical investigation of the roots of Polygala sibirica L.

  • AIM:To investigate the chemical constituents of the roots of Polygala sibirica L.(Polygalaceae) METHOD:The isolation was performed by solvent extraction and various chromatographic techniques,including silica gel,Sephadex LH-20,ODS,semi-preparative HPLC,and preparative TLC.The chemical structures were elucidated based on extensive spectroscopic analysis,including HR-ESI-MS and 1D-and 2D-NMR spectroscopic data.RESULTS:A total of sixteen compounds,including five xanthones(5,7-10),five saccharide esters(1,3,4,12,13),two flavonoids(14,16),two triterpenoids(11,15),one phenylpropanoid(6),and one benzophenone glycoside(2) were isolated.Their structures were determined as sibiricose A7(1),sibiriphenone A(2),polygalatenoside A(3),polygalatenoside C(4),lancerin(5),3,4,5-trimethoxycinnamic acid(6),6-hydroxy-1,2,3,7-tetramethoxyxanthone(7),1,3,7-trihydroxy-2-methoxyxanthone(8),onjixanthone II(9),1,2,3,6,7-pentamethoxyxanthone(10),presenegenin(11),3'-O-3,4,5-trimethoxycinnamoyl-6-O-4-methoxy benzoyl sucrose(12),tenuifoliside C(13),5,3'-dihydroxy-7,4'-dimethoxyflavonol-3-O-β-D-glucopyranoside(14),tenuifolin(15),and rhamnetin 3-O-β-D-glucopyranoside(16).CONCLUSION:Compounds 1 and 2 are two new compounds from P.sibirica.
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