XIA Gui-Yang, WANG Ling-Yan, ZHANG Jing-Fang, WU Yu-Zhuo, GE Guang-Bo, WANG Ya-Nan, LIN Peng-Cheng, LIN Sheng. Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase [J]. Chin J Nat Med, 2020, 18(1): 75-80.. doi: 10.1016/S1875-5364(20)30007-8
Citation: XIA Gui-Yang, WANG Ling-Yan, ZHANG Jing-Fang, WU Yu-Zhuo, GE Guang-Bo, WANG Ya-Nan, LIN Peng-Cheng, LIN Sheng. Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase [J]. Chin J Nat Med, 2020, 18(1): 75-80.. doi: 10.1016/S1875-5364(20)30007-8

Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase

  • Purpurolides D–F ( 13 ), three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system, were isolated from the endophytic fungus Penicillium purpurogenum IMM 003. Their structures were unambiguously elucidated based on extensive spectroscopic data analyses, 13C NMR chemical shifts calculations coupled with the DP4+ probability method, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 13 showed significant inhibitory activity against pancreatic lipase (PL). The result highlights that the presence of 3-hydroxylated decanoic acid moiety at C-14 is important for increasing the inhibition potency against PL.
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