About this Research Topic
Background—Human beings are “superorganisms”. There are over 1000 species bacteria and approximately 10 times the number of the host genes inhabiting in the mammalian gastrointestinal tract. Traditional Chinese Medicine (TCM) is an extremely complex systems with numerous components and multiple therapeutic targets of host. As a result, it is a great challenge for deciphering the therapeutic mechanisms of TCM. Currently, emerging evidence has highlighted that the variation of gut microbiota is an important factor for determining both pharmacokinetics and pharmacodynamics. Meanwhile, TCM therapy has been clearly recognized as association with the modulation on gut microbiota or metabolized by gut microbiota. As a result, it is of vital significance for investigating the involvement of gut microbiota in TCM research.
Goal—There are many factors involved in the actions of herbal medicine or TCM, in which gut microbiota is increasingly recognized as a critical factor in affecting drug efficacy. Currently, the compositional and functional evidence of gut microbiome in disease development is accumulating due to the fast advances in metagenomics and high-throughput omics technology, especially metabolomics. Therefore, gut microbiome is a promising target for investigating the mechanism underlying herbal medicine or TCM therapy.
Scope and information for Authors—The current special issue” Gut microbiome and TCM” welcomes manuscripts that are focused on investigating the gut microbiota involvement in herbal medicine or TCM study. Authors are encouraged to submit original articles, review article, and short communications associated with this special issue.
In particular, the topics of interest include, but are not limited to:
● Clinical or experimental studies on the role of gut microbiota in modulating herbal medicine or TCM efficacy.
● Gut microbiome-involvement in efficacy or toxicity of herbal-derived active components.
● Omics-based study on gut microbiome and herbal medicine or TCM.
● Functional study of gut microbiota-derived metabolites in the context of herbal medicine or TCM therapy.
5 keywords: Gut microbiota, TCM, metabolomics, metagenomics, pharmacology, herbal medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. All authors who want to submit to this topic，please contact to Guest Editor LI Hou-Kai, E-mail: email@example.com