A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides

AIM:To study the chemical constituents from the aerial parts of Trachelospermum jasminoides.METHODS:Compounds were isolated by various chromatographic methods and their structures were elucidated on the basis of spectral techniques.In addition,the inhibitory activity against HepG2 and HL-60 of compound 1 was evaluated.RESULTS:Five compounds were isolated and identified as 3',7-dimethoxyisoflavanone-4',5-di-O-β-D-glucopyranoside(1),tracheloside(2),nortrachelogenin 5'-C-β-glucopyranoside(3),luteolin-4'-O-β-D-rutinoside(4),and luteolin-7-O-β-D-glucopyranoside(5).CONCLUSION:Compound 1 is a new isoflavonoid glycoside.It showed weak inhibitory activity against HepG2 and HL-60 cancer cells with IC50 values of 131.5 and 58.2 μmol·L-1,respectively.