Cyclocarysaponins A - J, dammarane-type triterpenoid glycosides from the leaves of Cyclocarya paliurus

Ten previously undescribed dammarane-type triterpenoid glycosides, cyclocarysaponins A – J (1-10), were isolated from the leaves of Cyclocarya paliurus (Batal) Iljinskaja. The structures of these compounds were characterized by extensive analysis of 1D and 2D NMR as well as HRESIMS spectra. All isolates were tested for their cytotoxicities against five human cell lines (Bel-7402, Caski, BGC-823, A2780, and HCT-116). Of the tested compounds, compounds 1, 7, and 9 were found to have cytotoxic activities against one or more human cancer cell lines.