Traditional Chinese Medicines derived Natural Inhibitors of Ferroptosis on Ischemic Stroke

Ischemic stroke (IS) is a globally pervasive cerebrovascular disease caused by cerebrovascular occlusion and is associated with high morbidity and mortality. The intricate pathological mechanisms of ischemic stroke pose challenges for therapeutic drug development. Ferroptosis, a form of programmed cell death (PCD) characterized by iron overload and accumulation of lipid peroxidation products, is strongly associated with ischemic stroke. Traditional Chinese medicines (TCMs) have historically been used for ischemic stroke treatment. Therefore, numerous studies have focused on screening natural ferroptosis inhibitors in TCMs against ischemic stroke. This review explores the significance of ferroptosis in ischemic stroke and surveys current research on natural ferroptosis inhibitors from TCMs, aiming to provide a theoretical foundation for the development of anti-ischemic stroke therapeutic drugs.