XU Shuangyu, ZHANG Feng, TAO Linlan, JIANG Yangming, HUANG Tao, LI Yanan, HU Zhanxing, YANG Jue, HAO Xiaojiang, YUAN Chunmao. Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora [J].Chin J Nat Med, 2024, 22(3): 265-272. DOI: 10.1016/S1875-5364(24)60601-1
Citation: XU Shuangyu, ZHANG Feng, TAO Linlan, JIANG Yangming, HUANG Tao, LI Yanan, HU Zhanxing, YANG Jue, HAO Xiaojiang, YUAN Chunmao. Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora [J].Chin J Nat Med, 2024, 22(3): 265-272. DOI: 10.1016/S1875-5364(24)60601-1

Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora

  • Four new sesquiterpene lactones (SLs) (14), along with a biosynthetically related SL (5), have been isolated from the leaves of Magnolia grandiflora. Magrandate A (1) is notable as the first C18 homogemarane type SL, featuring a unique 1,7-dioxaspiro4.4nonan-6-one core. Compounds 2 and 3, representing the first instances of chlorine-substituted gemarane-type SL analogs in natural products, were also identified. The structures of these isolates were elucidated through a combination of spectroscopic data analysis, electronic circular dichroism calculations, and X-ray single-crystal diffraction analysis. All isolates demonstrated anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 cells. Notably, 35 showed a significant inhibitory effect on nitric oxide production, with IC50 values ranging from 0.79 to 4.73 μmol·L−1. Additionally, 4 and 5 exhibited moderate cytotoxic activities against three cancer cell lines, with IC50 values between 3.09 and 11.23 μmol·L−1.
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