DANG Wen, GUO Tingting, ZHOU Di, MENG Qingqi, FANG Mingxia, CHEN Gang, LIN Bin, HOU Yue, LI Ning. Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis [J].Chin J Nat Med, 2023, 21(0): 1-12. doi: 10.1016/S1875-5364(23)60522-9
Citation: DANG Wen, GUO Tingting, ZHOU Di, MENG Qingqi, FANG Mingxia, CHEN Gang, LIN Bin, HOU Yue, LI Ning. Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis [J].Chin J Nat Med, 2023, 21(0): 1-12. doi: 10.1016/S1875-5364(23)60522-9
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Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis

    Abstract
  • The resin of Ferula sinkiangensis has been traditionally used in treating gastrointestinal diseases, inflammation, lumps, various cancers, and alopecia areata. Its main bioactive component, sesquiterpene coumarin, has excellent therapeutic potential for neuroinflammation. Based on this, a structure-guided fractionation procedure isolated nine undescribed sesquiterpene coumarins from the resin of F. sinkiangensis. All isolates were identified and structurally elucidated through extensive physiochemical and spectroscopic analyses and calculated ECD. Anti-neuroinflammatory evaluation results indicated that compounds 2 , 3 , and 6 significantly inhibited NO production of LPS-stimulated BV2 cells with IC50 values from 1.63 to 12.25 μM.
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