FAN Kun, ZHANG Lanchun, TAN Bangyin, Guy S.S. Njateng, QIN Malong, GUO Ruirong, HUANG Xiaojuan, DING Cai-feng, GAO Weimin, ZHANG Rongping, YU Haofei. Antimicrobial indole alkaloids from Tabernaemontana corymbosa [J].Chin J Nat Med, 2023, 21(2): 146-153. doi: 10.1016/S1875-5364(23)60393-0
Citation: FAN Kun, ZHANG Lanchun, TAN Bangyin, Guy S.S. Njateng, QIN Malong, GUO Ruirong, HUANG Xiaojuan, DING Cai-feng, GAO Weimin, ZHANG Rongping, YU Haofei. Antimicrobial indole alkaloids from Tabernaemontana corymbosa [J].Chin J Nat Med, 2023, 21(2): 146-153. doi: 10.1016/S1875-5364(23)60393-0
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Antimicrobial indole alkaloids from Tabernaemontana corymbosa

    Abstract
  • Four unreported monoterpene indole alkaloids, tabernaecorymines B−E ( 1 − 4 ), together with twenty-one known indole alkaloids ( 5 − 25 ) were obtained from the stem bark of Tabernaemontana corymbosa. Their structures and absolute configurations were elucidated by extensive spectroscopy, quantum chemical calculations, DP4+ probability analyses and Mo2(OAc)4-induced electronic circular dichroism experiment. The antibacterial and antifungal activities of these compounds were evaluated and some of them showed significant activity against Staphylococcus aureus, Bacillus subtilis, Streptococcus dysgalactiae and Candida albicans.
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