XIA Huan, ZHANG Jing-Fang, WANG Ling-Yan, XIA Gui-Yang, WANG Ya-Nan, WU Yu-Zhuo, LIN Peng-Cheng, XIONG Liang, LIN Sheng. Bioactive neolignans and lignans from the roots of Paeonia lactiflora [J].Chin J Nat Med, 2022, 20(3): 210-214. doi: 10.1016/S1875-5364(22)60164-X
Citation: XIA Huan, ZHANG Jing-Fang, WANG Ling-Yan, XIA Gui-Yang, WANG Ya-Nan, WU Yu-Zhuo, LIN Peng-Cheng, XIONG Liang, LIN Sheng. Bioactive neolignans and lignans from the roots of Paeonia lactiflora [J].Chin J Nat Med, 2022, 20(3): 210-214. doi: 10.1016/S1875-5364(22)60164-X
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Bioactive neolignans and lignans from the roots of Paeonia lactiflora

    Abstract
  • Two new neolignans and one new lignan ( 1 – 3 ) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers through chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 μmol·L−1.
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