SHAO Si-Yuan, LI Ruo-Fei, SUN Hua, LI Shuai. New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity [J]. Chin J Nat Med, 2021, 19(5): 376-384. doi: 10.1016/S1875-5364(21)60036-5
Citation: SHAO Si-Yuan, LI Ruo-Fei, SUN Hua, LI Shuai. New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity [J]. Chin J Nat Med, 2021, 19(5): 376-384. doi: 10.1016/S1875-5364(21)60036-5
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New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity

    Abstract
  • Seven new triterpenoid saponins, including five ursane-type saponins, ilexchinenosides R–V ( 1 – 5 ), and two oleanane-type saponins, ilexchinenosides W–X ( 6 – 7 ), with four known triterpenoid saponins ( 8 – 11 ) were isolated from the leaves of Ilex chinensis. Their structures were elucidated by comprehensive spectroscopic 1D and 2D NMR and HR-ESI-MS data. Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization. Compounds 1 , 2 , 4 , 9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury in vitro.
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