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Yuan WANG, Jing LIN, Qi WANG, Kun SHANG, De-Bing PU, Rui-Han ZHANG, Xiao-Li LI, Xiao-Chang DAI, Xing-Jie ZHANG, Wei-Lie XIAO. Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana[J]. Chinese Journal of Natural Medicines, 2019, 17(12): 953-962.

Citation:

Yuan WANG, Jing LIN, Qi WANG, Kun SHANG, De-Bing PU, Rui-Han ZHANG, Xiao-Li LI, Xiao-Chang DAI, Xing-Jie ZHANG, Wei-Lie XIAO. Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana[J]. Chinese Journal of Natural Medicines, 2019, 17(12): 953-962.

Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana

摘要

Abstract: Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A-F ( 1-6 ), together with seven analogues ( 7-13 ). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1 , 2 , 3 , 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

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