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Jian ZHANG, Hua LI, Yong LI, Zi-Wei LI, Chen-Chen SANG, Mei-Hua GAO, Dong-Mei ZHANG, Xiao-Qi ZHANG, Wen-Cai YE. Four new corynanthe-type alkaloids from the roots of Alstonia scholaris[J]. Chinese Journal of Natural Medicines, 2019, 17(12): 918-923.
Citation: Jian ZHANG, Hua LI, Yong LI, Zi-Wei LI, Chen-Chen SANG, Mei-Hua GAO, Dong-Mei ZHANG, Xiao-Qi ZHANG, Wen-Cai YE. Four new corynanthe-type alkaloids from the roots of Alstonia scholaris[J]. Chinese Journal of Natural Medicines, 2019, 17(12): 918-923.
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Four new corynanthe-type alkaloids from the roots of Alstonia scholaris

    摘要
  • Abstract: Four new corynanthe-type alkaloids, meloslines C-F ( 1-4 ), together with four known ones ( 5-8 ) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.

     

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