Abstract:
Jatrogricaine A (
1 ), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (
2-9 ) were isolated from the stems of
Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of
1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities
in vitro, and compound
3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC
50 of 13.44 ±0.28 μmol·L
-1, being comparable to the positive control, quercetin (IC
50 17.00 ±2.10 μmol·L
-1).