Abstract:
Romipeptides A and B (
1 and
2 ), two new romidepsin derivatives, and three known compounds, chromopeptide A (
3 ), romidepsin (
4 ) and valine-leucine dipeptide (
5 ) were isolated from the fermentation broth of
Chromobacterium violaceum No. 968. Their structures were elucidated by interpretation of their UV, HR-ESI-MS and NMR spectra. The absolute configuration of compound
1 and
2 were established by single crystal X-ray diffraction analysis. Compounds
1 -
5 were evaluated for their anti-proliferative activities against three human cancer cell lines, SW620, HL60, and A549. The results showed most of these compounds exhibited antitumor activities
in vitro, in which compound
2 displayed potent cytotoxicity to SW620, HL60 and A549 cell lines, with IC
50 of 12.5, 6.7 and 5.7 nmol·L
-1, respectively.