A lignin glycoside and a nortriterpenoid from <i>Kadsura coccinea</i>

A lignin glycoside and a nortriterpenoid from Kadsura coccinea

摘要: AIM:To study the chemical constituents of the roots and stem bark of Kadsura coccinea.METHOD:Compounds were isolated by column chromatography on silica gel and Sephadex LH-20,and finally purified by prep-HPLC.Their structures were elucidated by extensive spectroscopic methods,including 1D-and 2D-NMR,and HR-ESI-MS.RESULTS:Two compounds were determined as(7'S,8'S,8R)-(8,8')-dimethyl-4,4'-dihydroxy-5,3'-dimethoxy-5'-cyclolignan glucoside(1) and micrandiactone H(2),respectively.CONCLUSION:Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide(NO) production in lipopolysaccharide-induced RAW264.7 macrophages.

Abstract: AIM:To study the chemical constituents of the roots and stem bark of Kadsura coccinea.METHOD:Compounds were isolated by column chromatography on silica gel and Sephadex LH-20,and finally purified by prep-HPLC.Their structures were elucidated by extensive spectroscopic methods,including 1D-and 2D-NMR,and HR-ESI-MS.RESULTS:Two compounds were determined as(7'S,8'S,8R)-(8,8')-dimethyl-4,4'-dihydroxy-5,3'-dimethoxy-5'-cyclolignan glucoside(1) and micrandiactone H(2),respectively.CONCLUSION:Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide(NO) production in lipopolysaccharide-induced RAW264.7 macrophages.