Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu
Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu
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摘要: AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus(Bull.) Murrill.METHOD:Compounds were isolated and purified by various chromatographic techniques.The structure of the new compound was determined by interpretation of MS and 1D-,2D-NMR spectroscopic data,while the known compounds were identified by comparison of their data with those reported.RESULTS:Three mycophenolic acid derivatives,6-((2E,6E)-3,7-dimethyldeca-2,6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(1),6-((2E,6E)-3,7,11-trimethyldedoca-2,6,10-trienyl)-5,7-dihydroxy-4-methylphtanlan-1-one(2),and 6-((2E,6E)-3,7,11-trimethyldedoca-2,6,10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(3) were isolated.CONCLUSION:Among them,compound 1 was new,and compound 2 exhibited moderate cytotoxicity against HL-60,SMMC-7721,A-549,and MCF-7 cells,with IC50 values of 39.1,31.1,27.4,and 35.7 μmol·L-1,respectively.Abstract: AIM:To investigate the chemical constituents of the cultures of Laetiporus sulphureus(Bull.) Murrill.METHOD:Compounds were isolated and purified by various chromatographic techniques.The structure of the new compound was determined by interpretation of MS and 1D-,2D-NMR spectroscopic data,while the known compounds were identified by comparison of their data with those reported.RESULTS:Three mycophenolic acid derivatives,6-((2E,6E)-3,7-dimethyldeca-2,6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(1),6-((2E,6E)-3,7,11-trimethyldedoca-2,6,10-trienyl)-5,7-dihydroxy-4-methylphtanlan-1-one(2),and 6-((2E,6E)-3,7,11-trimethyldedoca-2,6,10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one(3) were isolated.CONCLUSION:Among them,compound 1 was new,and compound 2 exhibited moderate cytotoxicity against HL-60,SMMC-7721,A-549,and MCF-7 cells,with IC50 values of 39.1,31.1,27.4,and 35.7 μmol·L-1,respectively.
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