• 中文核心期刊要目总览
  • 中国科技核心期刊
  • 中国科学引文数据库（CSCD）
  • 中国科技论文与引文数据库（CSTPCD）
  • 中国学术期刊文摘数据库（CSAD）
  • 中国学术期刊（网络版）（CNKI）
  • 中文科技期刊数据库
  • 万方数据知识服务平台
  • 中国超星期刊域出版平台
  • 国家科技学术期刊开放平台
  • 荷兰文摘与引文数据库（SCOPUS）
  • 日本科学技术振兴机构数据库（JST）
高级检索
CAO Xing-Fen, WANG Jun-Song, WANG Peng-Ran, KONG Ling-Yi. Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity[J]. 中国天然药物, 2014, 12(8): 628-631.
引用本文: CAO Xing-Fen, WANG Jun-Song, WANG Peng-Ran, KONG Ling-Yi. Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity[J]. 中国天然药物, 2014, 12(8): 628-631.
shu
CAO Xing-Fen, WANG Jun-Song, WANG Peng-Ran, KONG Ling-Yi. Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity[J]. Chinese Journal of Natural Medicines, 2014, 12(8): 628-631.
Citation: CAO Xing-Fen, WANG Jun-Song, WANG Peng-Ran, KONG Ling-Yi. Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity[J]. Chinese Journal of Natural Medicines, 2014, 12(8): 628-631.
shu

Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity

Triterpenes from the stem bark of Mitragyna diversifolia and their cytotoxic activity

    摘要
  • 摘要: AIM:To study the chemical constituents and bioactivity of the stem bark of Mitragyna diversifolia.METHOD:Compounds were isolated by various chromatographic methods.Their structures were elucidated on the basis of spectroscopic techniques(IR,UV,MS,and NMR),and they were evaluated for their cytotoxic activities by the MTT method.RESULTS:Eight triterpenes were isolated and identified as 3,6,19-trihydroxy-urs-12-en-28-oic acid(1),3,6,19-trihydroxy-urs-12-en-28-oic acid(2),3-oxo-6-19-dihydroxy-urs-12-en-28-oic acid(3),3,6,19-trihydroxy-urs-12-en-24,28-dioic acid 24-methyl ester(4),3,6,19,24-tetrahydroxy-urs-12-en-28-oic acid(5),rotundic acid(6),23-nor-24-exomethylene-3,6,19-trihydroxy-urs-12-en-28-oic acid(7),and pololic acid(8),respectively.All of the isolates were tested against two human tumor cell lines,MCF-7(breast) and HT-29(colon).CONCLUSION:Compound 1 was a new triterpene.Compounds 5-7 exhibited potent inhibitory effects on the growth of MCF-7 and HT-29 cells,and the others showed no cytotoxicity.

     

    Abstract: AIM:To study the chemical constituents and bioactivity of the stem bark of Mitragyna diversifolia.METHOD:Compounds were isolated by various chromatographic methods.Their structures were elucidated on the basis of spectroscopic techniques(IR,UV,MS,and NMR),and they were evaluated for their cytotoxic activities by the MTT method.RESULTS:Eight triterpenes were isolated and identified as 3,6,19-trihydroxy-urs-12-en-28-oic acid(1),3,6,19-trihydroxy-urs-12-en-28-oic acid(2),3-oxo-6-19-dihydroxy-urs-12-en-28-oic acid(3),3,6,19-trihydroxy-urs-12-en-24,28-dioic acid 24-methyl ester(4),3,6,19,24-tetrahydroxy-urs-12-en-28-oic acid(5),rotundic acid(6),23-nor-24-exomethylene-3,6,19-trihydroxy-urs-12-en-28-oic acid(7),and pololic acid(8),respectively.All of the isolates were tested against two human tumor cell lines,MCF-7(breast) and HT-29(colon).CONCLUSION:Compound 1 was a new triterpene.Compounds 5-7 exhibited potent inhibitory effects on the growth of MCF-7 and HT-29 cells,and the others showed no cytotoxicity.

     

    • HTML全文
    • 参考文献(12)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回