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SUN Jian-Bo, QU Wei, GUAN Fu-Qin, LI Lin-Zhen, LIANG Jing-Yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius[J]. 中国天然药物, 2014, 12(3): 222-224.
引用本文: SUN Jian-Bo, QU Wei, GUAN Fu-Qin, LI Lin-Zhen, LIANG Jing-Yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius[J]. 中国天然药物, 2014, 12(3): 222-224.
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SUN Jian-Bo, QU Wei, GUAN Fu-Qin, LI Lin-Zhen, LIANG Jing-Yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius[J]. Chinese Journal of Natural Medicines, 2014, 12(3): 222-224.
Citation: SUN Jian-Bo, QU Wei, GUAN Fu-Qin, LI Lin-Zhen, LIANG Jing-Yu. A new quinoline alkaloid from the roots of Dictamnus angustifolius[J]. Chinese Journal of Natural Medicines, 2014, 12(3): 222-224.
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A new quinoline alkaloid from the roots of Dictamnus angustifolius

A new quinoline alkaloid from the roots of Dictamnus angustifolius

    摘要
  • 摘要: AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet(Rutaceae).METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis.RESULTS:A new quinoline alkaloid,5-methoxylrobustine(1),along with five known quinoline alkaloids were obtained,and their structures were identified as dictamnine(2),robustine(3),isopteleine(4),γ-fagarine(5),and skimmianine(6).Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells(MCF7).CONCLUSION:Compound 1 is a new quinoline alkaloid.Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.

     

    Abstract: AIM:To investigate the quinoline alkaloids from the roots of Dictamnus angustifolius G.Don ex Sweet(Rutaceae).METHOD:The quinoline alkaloids were isolated by various column chromatographic methods and their structures were elucidated on the basis of spectral analysis.RESULTS:A new quinoline alkaloid,5-methoxylrobustine(1),along with five known quinoline alkaloids were obtained,and their structures were identified as dictamnine(2),robustine(3),isopteleine(4),γ-fagarine(5),and skimmianine(6).Cytotoxicity testing of these alkaloids showed that all of them had weak cytotoxic activities against human breast cancer cells(MCF7).CONCLUSION:Compound 1 is a new quinoline alkaloid.Alkaloid 3 showed stronger anti-proliferation effect than the other alkaloids.

     

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