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MENG Zhao-Qing, LIU Wen-Jun, LI Zan, LIN Yun-Wei, LI Meng-Xuan, AN Shi-Ying, DING Gang, WANG Zhen-Zhong, XIAO Wei, XU Jin-Yi. Transformation of strictosamide to vincoside lactam by acid catalysis[J]. 中国天然药物, 2013, 11(2): 188-192.
引用本文: MENG Zhao-Qing, LIU Wen-Jun, LI Zan, LIN Yun-Wei, LI Meng-Xuan, AN Shi-Ying, DING Gang, WANG Zhen-Zhong, XIAO Wei, XU Jin-Yi. Transformation of strictosamide to vincoside lactam by acid catalysis[J]. 中国天然药物, 2013, 11(2): 188-192.
shu
MENG Zhao-Qing, LIU Wen-Jun, LI Zan, LIN Yun-Wei, LI Meng-Xuan, AN Shi-Ying, DING Gang, WANG Zhen-Zhong, XIAO Wei, XU Jin-Yi. Transformation of strictosamide to vincoside lactam by acid catalysis[J]. Chinese Journal of Natural Medicines, 2013, 11(2): 188-192.
Citation: MENG Zhao-Qing, LIU Wen-Jun, LI Zan, LIN Yun-Wei, LI Meng-Xuan, AN Shi-Ying, DING Gang, WANG Zhen-Zhong, XIAO Wei, XU Jin-Yi. Transformation of strictosamide to vincoside lactam by acid catalysis[J]. Chinese Journal of Natural Medicines, 2013, 11(2): 188-192.
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Transformation of strictosamide to vincoside lactam by acid catalysis

Transformation of strictosamide to vincoside lactam by acid catalysis

    摘要
  • 摘要: AIM:To identify the structure of the acid-catalyzed product of strictosamide and explore the reaction mechanism.METHODS:The acid-catalyzed reaction process of strictosamide was monitored by HPLC,and a macroporous resin was used to purify the reaction solution.The structure of the product was confirmed by MS,NMR,and ROESY spectra.RESULTS:The acid-catalyzed transformation yield from strictosamide to vincoside lactam was 52%.CONCLUSION:The reaction mechanism of the transformation from strictosamide to vincoside lactam may be related to the stability of the three-dimensional configuration of the compound.These results offer a new way to obtain vincoside lactam from the widely distributed indole alkaloid strictosamide by acid-catalysis.

     

    Abstract: AIM:To identify the structure of the acid-catalyzed product of strictosamide and explore the reaction mechanism.METHODS:The acid-catalyzed reaction process of strictosamide was monitored by HPLC,and a macroporous resin was used to purify the reaction solution.The structure of the product was confirmed by MS,NMR,and ROESY spectra.RESULTS:The acid-catalyzed transformation yield from strictosamide to vincoside lactam was 52%.CONCLUSION:The reaction mechanism of the transformation from strictosamide to vincoside lactam may be related to the stability of the three-dimensional configuration of the compound.These results offer a new way to obtain vincoside lactam from the widely distributed indole alkaloid strictosamide by acid-catalysis.

     

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