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Cheng-Yao MA, Jia-Hui LU, Xiang LI, Xiao LIU, Jian-Wei CHEN. Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa[J]. Chinese Journal of Natural Medicines, 2019, 17(4): 291-297.

Citation:

Cheng-Yao MA, Jia-Hui LU, Xiang LI, Xiao LIU, Jian-Wei CHEN. Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa[J]. Chinese Journal of Natural Medicines, 2019, 17(4): 291-297.

Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

摘要

Abstract: Eight new annonaceous acetogenins, squamotin A-D ( 1-4 ), annosquatin Ⅳ-V ( 5 and 6 ), muricin O ( 7 ) and squamosten B ( 8 ), together with four known ones ( 9-12 ) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1-9 against three multidrug resistance cell lines were evaluated. All tested compounds showed strong cytotoxicity.

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