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奥乌力吉, 王青虎, 斯钦, 牡丹, 萨仁图雅, 代那音台, 都日斯哈拉图. 山沉香中两个新倍半萜的结构鉴定和抗菌活性[J]. 中国天然药物, 2012, 10(6): 477-480.
引用本文: 奥乌力吉, 王青虎, 斯钦, 牡丹, 萨仁图雅, 代那音台, 都日斯哈拉图. 山沉香中两个新倍半萜的结构鉴定和抗菌活性[J]. 中国天然药物, 2012, 10(6): 477-480.
shu
AO Wu-Li-Ji, WANG Qing-Hu, Si-Qin, Mu-Dan, Sa-Ren-Tu-Ya, DAI Na-Yin-Tai, Du-Ri-Si-Ha-La-Tu. The structural elucidation and antimicrobial activities of two new sesquiterpenes from Syringa pinnatifolia Hemsl.[J]. Chinese Journal of Natural Medicines, 2012, 10(6): 477-480.
Citation: AO Wu-Li-Ji, WANG Qing-Hu, Si-Qin, Mu-Dan, Sa-Ren-Tu-Ya, DAI Na-Yin-Tai, Du-Ri-Si-Ha-La-Tu. The structural elucidation and antimicrobial activities of two new sesquiterpenes from Syringa pinnatifolia Hemsl.[J]. Chinese Journal of Natural Medicines, 2012, 10(6): 477-480.
shu

山沉香中两个新倍半萜的结构鉴定和抗菌活性

The structural elucidation and antimicrobial activities of two new sesquiterpenes from Syringa pinnatifolia Hemsl.

    摘要
  • 摘要: 目的:对山沉香中化学成分的分离鉴定和抗菌活性进行研究。方法:运用柱层析等方法对山沉香氯仿层进行分离纯化,并通过波谱解析和理化鉴别进行结构鉴定。同时对分离得到化合物的抗菌活性进行了评估。结果:从山沉香分离得到2个倍半萜类化合物:guai-9-en-4-ol (1)和14, 15-dinorguai-1, 11-dien-9, 10-dione (2)。化合物1对Bacillus coagulas具有良好的活性而对Proteous vulgaris活性较差;化合物2对Eschecheria coli具有良好的活性而对Staphylococcus aureus活性较差。结论:化合物1和2为新化合物,具有较好的抗菌活性。

     

    Abstract: AIM: To study the chemical constituents of Syringa pinnatifolia Hemsl. and their antibacterial and antifungal activities. METHODS: The CHCl3-soluble fraction was separated by chromatography, and the structures of the new compounds were elucidated by spectral experiments. Antimicrobial activity of the compounds was evaluated against various bacteria and fungi. RESULTS: Two new sesquiterpenes, guai-9-en-4-ol (1) and 14, 15-dinorguai-1, 11-dien-9, 10-dione (2) were isolated from the stem of Syringa pinnatifolia Hemsl. var. alashanensis. Compound 1 is more active against Bacillus coagulas, while being less active against Proteus vulgaris. Compound 2 shows good activity against Escherichia coli, and is less active against Staphylococcus aureus. CONCLUSIONS: Compounds 1 and 2 are new compounds, and when evaluated against various bacteria showed good results.

     

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