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王吉鸿, 纪明慧, 舒火明, 陈光英, 宋小平, 王菁. 沙煲暗罗根的化学成分[J]. 中国天然药物, 2012, 10(4): 303-306.
引用本文: 王吉鸿, 纪明慧, 舒火明, 陈光英, 宋小平, 王菁. 沙煲暗罗根的化学成分[J]. 中国天然药物, 2012, 10(4): 303-306.
shu
WANG Ji-Hong, JI Ming-Hui, SHU Huo-Ming, CHEN Guang-Ying, SONG Xiao-Ping, WANG Jing. Chemical constituents from the roots of Polyalthia obliqua[J]. Chinese Journal of Natural Medicines, 2012, 10(4): 303-306.
Citation: WANG Ji-Hong, JI Ming-Hui, SHU Huo-Ming, CHEN Guang-Ying, SONG Xiao-Ping, WANG Jing. Chemical constituents from the roots of Polyalthia obliqua[J]. Chinese Journal of Natural Medicines, 2012, 10(4): 303-306.
shu

沙煲暗罗根的化学成分

Chemical constituents from the roots of Polyalthia obliqua

    摘要
  • 摘要: 目的:对沙煲暗罗根的化学成分进行研究。方法:运用硅胶和Sephadex LH-20柱色谱,以及制备薄层色谱等方法分离纯化化合物,通过波谱数据和理化性质鉴定结构。结果:从沙煲暗罗根中得到10个化合物:5, 7-二羟基-8-甲酰基-6-甲基黄烷酮(1), demethoxymatteucinol(2), 5, 7-二羟基-6-甲基-8-甲酰基黄酮(3), 5, 7-二羟基-6-甲酰基-8-甲基黄酮(4), Marcanine A (5),suberosol (6), -谷甾醇(7),香草醛(8),肉桂酸(9),烟酸(10)。结论:化合物1-4为首次从该属中分离得到,所有化合物为首次从该植物中分离得到。化合物6对人肿瘤细胞SPC-A-1和SGC-7901显示有细胞毒性。

     

    Abstract: AIM: To study the chemical constituents from the roots of Polyalthia obliqua. METHODS: The constituents were isolated and purified by silica gel column chromatography, Sephadex LH-20 and preparative TLC. Their structures were identified on the basis of spectral data and physiochemical properties. RESULTS: Ten compounds were isolated and their structures were elucidated as 5,7-dihydroxy-8-formyl-6-methylflavanone (1), demethoxymatteucin ol (2), 5,7-dihydroxy-6-methyl-8-formylflavone (3), 5, 7-dihydroxy- 6-formyl-8-methylflavone (4), marcanine A (5), suberosol (6), -sitosteral (7), vanillin (8), cinnamic acid (9) and nicotinic acid (10). CONCLUSION: Compounds 1-4 were reported from the genus for the first time. All the compounds were isolated from this plant for the first time. Compound 6 showed cytotoxicity against human cancer cell lines SPC-A-1 and SGC-7901.

     

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