银线草中一个新的桉烷型倍半萜内酯

A new eudesmane sesquiterpenoid lactone from Chloranthus japonicus

摘要: 目的:研究银线草(Chloranthus japonicus)全株的化学成分;方法:利用各种色谱方法进行分离;通过各种光谱方法鉴定化合物结构;结果:从银线草分离得到1个新的倍半萜chlojaponilactone A(1)和5个已知倍半萜:白术内酯III(2),neolitacumone B(3), 10-hydroxy-1-oxoeremophila-7(11), 8(9)-diene-8, 12-olide(4),银线草内酯C(5)和银线草内酯H(6);结论:chlojaponilactone A(1)为新的桉烷型倍半萜内酯,化合物3和4首次从该植物中分离得到。

Abstract: AIM: To study the chemical constituents of the whole plant of Chloranthus japonicus. METHODS: Compounds were isolated and purified by column chromatography. Their structures were elucidated on the basis of spectroscopic methods. RESULTS: Six sesquiterpenoids were obtained and their structures were identified as chlojaponilactone A (1), atractylenolide III (2), neolitacumone B (3), 10-hydroxy-1-oxoeremophila-7(11), 8(9)-diene-8, 12-olide (4), shizukanolide C (5), and shizukanolide H (6). CONCLUSION: Compound 1 is a new eudesmane-type sesquiterpenoid lactone, and compounds 3 and 4 have been isolated from this species for the first time.