叶瓜参中的三个脑苷脂

Three cerebrosides from the sea cucumber Cucumaria frondosa

摘要: 目的:研究叶瓜参化学成分。方法:对叶瓜参的65%乙醇提取物中小极性部分进行行分离纯化,得到脑苷脂分子种3,对脑苷脂分子种3应用高效液相色谱进一步分离纯化,得到3个脑苷脂单体, CF-3-1(1)、CF-3-2(2)和CF-3-3(3)。结果:根据化合物的波谱数据和化学方法鉴定了其结构。结论:三个化合物为首次从叶瓜参中分离得到,首次得到化合物2和3的单体化合物。

Abstract: AIM: To study the chemical constituents of the sea cucumber Cucumaria frondosa. METHODS: Three sphingosine-type glucocerebrosides, CF-3-1, CF-3-2 and CF-3-3 were isolated by means of high performance liquid chromatography (HPLC) from a cerebroside molecular species 3 which was obtained from the less polar fraction of the 65% EtOH extract of the sea cucumber Cucumaria frondosa Gunnerus. RESULTS: The structures of these cerebrosides were determined on the basis of chemical and spectroscopic evidences. CONCLUSION: Three compounds were isolated from the sea cucumber Cucumaria frondosa for the first time. CF-3-3 and CF-3-2 were obtained as pure compounds for the first time.