Abstract:
Tagetones A (
1 ) and B (
2 ), two new monocyclic diterpenoids were isolated from the
n-hexane fraction of fresh flowers of
Tagetes minuta L. (Asteraceae). Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound
1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC
50 values being 4.68 and 4.24 μmol·L
-1, respectively, compared to doxorubicin (IC
50 0.13 and 1.12 μmol·L
-1, respectively). Compound
2 also exhibited significant activity against HCT116 cancer cells (IC
50, 6.30 μmol·L
-1).