Abstract:
The fruits of
Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new
C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new
C-geranylated flavone, paucatalinone C (
1 ) and five known
C-geranylated flavanones (
2 -
6 ) were isolated. In addition, a total of 34
C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH
2Cl
2 extract of
P.
catalpifolia. Futhermore, anti-aging effects of isolated compounds were evaluated
in vitro with premature senescent 2BS cells induced by H
2O
2. Phytochemical results indicated that
P.
catalpifolia was a natural resource of abundant
C-geranylated flavonoids. Diplacone (
3 ) and paucatalinone A (
5 ) were the potent anti-aging agents in the premature senescent 2BS cells induced by H
2O
2 and the C-geranyl substituent may be an important factor because of its lipophilic character.