Abstract:
Three new labdane diterpenoids, leojaponicone A (
1 ), isoleojaponicone A (
2 ) and methylisoleojaponicone A (
3 ), were isolated from the herb of
Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1D and 2D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested
in vitro for their acetylcholinesterase and
α-glucosidase inhibitory activity. Compounds
1 -
3 exhibited low inhibitory effects on
α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.
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