Cytotoxic diaporindene and tenellone derivatives from the fungus Phomopsis lithocarpus

Abstract: Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E−I ( 1 − 5 ), and four new benzophenone analogues named tenellones J−M ( 6 − 9 ) were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD calculation and single-crystal X-ray diffraction analysis. The potential anti-tumor activities of compounds 1 − 9 against four tumor cell lines SF-268, MCF-7, HepG-2, and A549 were evaluated using the SRB method. Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC₅₀ value of 11.36 μmol·L⁻¹.