Abstract:
Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1
H-indene derivatives named diaporindenes E−I (
1 −
5 ), and four new benzophenone analogues named tenellones J−M (
6 −
9 ) were isolated from the deep-sea sediment-derived fungus
Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD calculation and single-crystal X-ray diffraction analysis. The potential anti-tumor activities of compounds
1 −
9 against four tumor cell lines SF-268, MCF-7, HepG-2, and A549 were evaluated using the SRB method. Compound
7 exhibited cytotoxic activity against the SF-268 cell line with an IC
50 value of 11.36 μmol·L
−1.