Abstract:
Biotransformation of
α-asarone by
Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans, (+) (7
S, 8
S, 7′
S, 8′
R)
iso-magnosalicin (
1a )/(−) (7
R, 8
R, 7'
R, 8′
S)
iso-magnosalicin (
1b ) and (+) (7
R, 8
R, 7′
S, 8'
R) magnosalicin (
2a )/(−) (7
S, 8
S, 7′
R, 8'
S) magnosalicin (
2b ), and four known metabolites, (±) acoraminol A (
3 ), (±) acoraminol B (
4 ), asaraldehyde (
5 ), and 2, 4, 5-trimethoxybenzoic acid (
6 ). Their structures, including absolute configurations, were determined by extensive analysis of NMR spectra, X-ray crystallography, and quantum chemical ECD calculations. The cytotoxic activity and A
β42 aggregation inhibitory activity of all the compounds were evaluated. Compound
2 displayed significant anti-A
β42 aggregation activity with an inhibitory rate of 60.81% (the positive control EGCG: 69.17%). In addition, the biotransformation pathway of
α-asarone by
Alternaria longipes CGMCC 3.2875 was proposed.
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