doi:10.1016/S1875-5364(21)60075-4

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XIA Huan, XIA Gui-Yang, WANG Ling-Yan, WANG Min, WANG Ya-Nan, LIN Peng-Cheng, LIN Sheng. Bioactive sesquineolignans from the twigs of Litsea cubeba [J].Chin J Nat Med, 2021, 19(10): 796-800. doi: 10.1016/S1875-5364(21)60075-4

Citation:

XIA Huan, XIA Gui-Yang, WANG Ling-Yan, WANG Min, WANG Ya-Nan, LIN Peng-Cheng, LIN Sheng. Bioactive sesquineolignans from the twigs of Litsea cubeba [J].Chin J Nat Med, 2021, 19(10): 796-800. doi: 10.1016/S1875-5364(21)60075-4

Bioactive sesquineolignans from the twigs of Litsea cubeba

摘要

Abstract: In a continuing search for biological natural products with structure diversity from traditional Chinese herbs, five new sesquineolignans ( 1 − 5 ) were isolated from an ethyl acetate extract of the twigs of Litsea cubeba. Their structures were elucidated based on MS, 1D and 2D NMR spectroscopic data, as well as experimental electronic circular dichroism (ECD) spectra. Compounds 1−5 showed moderate inhibitory effects against LPS-induced NO production in RAW264.7 macrophages, with IC₅₀ values of 16.2, 20.2, 22.1, 15.1, and 16.6 μmol·L⁻¹, respectively.

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