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SONG Ning-Ning, YANG Lei-Min, ZHANG Min-Jie, AN Ren-Feng, LIU Wei, HUANG Xue-Feng. Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities [J]. Chin J Nat Med, 2021, 19(1): 63-69. doi: 10.1016/S1875-5364(21)60007-9
Citation: SONG Ning-Ning, YANG Lei-Min, ZHANG Min-Jie, AN Ren-Feng, LIU Wei, HUANG Xue-Feng. Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities [J]. Chin J Nat Med, 2021, 19(1): 63-69. doi: 10.1016/S1875-5364(21)60007-9
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Triterpenoid saponins and phenylpropanoid glycoside from the roots of Ardisia crenata and their cytotoxic activities

    摘要
  • Abstract: Two new triterpenoid saponins, ardisicrenoside R and S ( 1 and 2 ), and one new phenylpropanoid glycoside, ardicrephenin ( 3 ), along with five known compounds ( 4 − 8 ), were isolated from roots of Ardisia crenata. Their structures were elucidated on the basis of NMR spectroscopic data and chemical methods. Compounds 2 − 7 were evaluated for their cytotoxic activities against A549, MCF-7, HepG2 and MDA-MB-231 cell lines by MTT assay. Ardicrenin ( 6 ) showed significant cytotoxicity, with IC50 values of 1.17 ± 0.01, 1.19 ± 0.06, 3.52 ± 0.23, and 16.61 ± 1.02 μmol·L−1, respectively.

     

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