Abstract:
Two new triterpenoid saponins, ardisicrenoside R and S (
1 and
2 ), and one new phenylpropanoid glycoside, ardicrephenin (
3 ), along with five known compounds (
4 −
8 ), were isolated from roots of
Ardisia crenata. Their structures were elucidated on the basis of NMR spectroscopic data and chemical methods. Compounds
2 −
7 were evaluated for their cytotoxic activities against A549, MCF-7, HepG2 and MDA-MB-231 cell lines by MTT assay. Ardicrenin (
6 ) showed significant cytotoxicity, with IC
50 values of 1.17 ± 0.01, 1.19 ± 0.06, 3.52 ± 0.23, and 16.61 ± 1.02 μmol·L
−1, respectively.