doi:10.1016/S1875-5364(20)60040-1

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LI Wei, WEI Jing, CHEN Dao-Ying, WANG Mei-Jing, SUN Yang, JIAO Fang-Wen, JIAO Rui-Hua, TAN Ren-Xiang, GE Hui-Ming. Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410 [J]. Chin J Nat Med, 2020, 18(12): 957-960. doi: 10.1016/S1875-5364(20)60040-1

Citation:

LI Wei, WEI Jing, CHEN Dao-Ying, WANG Mei-Jing, SUN Yang, JIAO Fang-Wen, JIAO Rui-Hua, TAN Ren-Xiang, GE Hui-Ming. Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410 [J]. Chin J Nat Med, 2020, 18(12): 957-960. doi: 10.1016/S1875-5364(20)60040-1

Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410

摘要

Abstract: Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives, arthrianhydride A ( 1) and B ( 2) , along with three known compounds 3 − 5 , were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp. NF2410. The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data. Furthermore, compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.

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