doi:10.1016/S1875-5364(20)60039-5

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DAI Li-Ping, WANG Zi-Shen, WANG Hao-Xin, LU Chun-Hua, SHEN Yue-Mao. Shunt products of aminoansamycins from aas1 overexpressed mutant strain of Streptomyces sp. S35 [J]. Chin J Nat Med, 2020, 18(12): 952-956. doi: 10.1016/S1875-5364(20)60039-5

Citation:

DAI Li-Ping, WANG Zi-Shen, WANG Hao-Xin, LU Chun-Hua, SHEN Yue-Mao. Shunt products of aminoansamycins from aas1 overexpressed mutant strain of Streptomyces sp. S35 [J]. Chin J Nat Med, 2020, 18(12): 952-956. doi: 10.1016/S1875-5364(20)60039-5

Shunt products of aminoansamycins from aas1 overexpressed mutant strain of Streptomyces sp. S35

摘要

Abstract: Constitutively expression of the pathway-specific activators is an effective method to activate silent gene clusters and improve natural product production. In this study, nine shunt products of aminoansamycins ( 1−9 ) were identified from a recombinant mutant strain S35-LAL by overexpressed the large-ATP-binding regulator of the LuxR family (LAL) gene aas1 in Streptomyces sp. S35. All the compounds showed no anti-microbial, anti-T3SS and cytotoxic activities.

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