Abstract:
Four new compounds, asperisocoumarin G (
1 ), asperisocoumarin H (
2 ), (±)-asperisocoumarin I (±)-
3 , along with the known pergillin (
4 ) and penicisochroman L (
5 ) were isolated from a mangrove endophytic fungus
Aspergillus sp. 085242 by further chemical investigation. The structures of the new compounds, including their absolute configurations, were established by analysis of HR-ESI-MS and NMR spectroscopic data, and ECD calculation. Asperisocoumarins G-I (
1 −
3 ) were new isocoumarins belonging to the class of furo3, 2-hisocoumarins which are rarely found in natural sources. All of the isolated compounds were evaluated for their
α-glucosidase inhibitory effects, and compounds
1 and
4 showed moderate
α-glucosidase inhibitory activity, respectively. In an antimicrobial test, the racemate of
3 showed antibacterial activity against
Salmonella.