doi:10.1016/S1875-5364(20)60013-9

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ZHANG Zi-Pei, XUE Wan-Ying, HU Jian-Xing, XIONG De-Cai, WU Yan-Fen, YE Xin-Shan. Novel carbohydrate-triazole derivatives as potential α -glucosidase inhibitors [J]. Chin J Nat Med, 2020, 18(10): 729-737. doi: 10.1016/S1875-5364(20)60013-9

Citation:

ZHANG Zi-Pei, XUE Wan-Ying, HU Jian-Xing, XIONG De-Cai, WU Yan-Fen, YE Xin-Shan. Novel carbohydrate-triazole derivatives as potential α -glucosidase inhibitors [J]. Chin J Nat Med, 2020, 18(10): 729-737. doi: 10.1016/S1875-5364(20)60013-9

Novel carbohydrate-triazole derivatives as potential α-glucosidase inhibitors

摘要

Abstract: A series of novel pyrano2, 3-dtrizaole compounds were synthesized and their α-glucosidase inhibitory activities were evaluated by in vitro enzyme assay. The experimental data demonstrated that compound 10f showed up to 10-fold higher inhibition (IC₅₀74.0 ± 1.3 μmol·L⁻¹) than acarbose. The molecular docking revealed that compound 10f could bind to α-glucosidase via the hydrophobic, π-π stacking, and hydrogen bonding interactions. The results may benefit further structural modifications to find new and potent α-glucosidase inhibitors.

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