Abstract:
Three new indole alkaloids, flueindolines A–C (
1 –
3 ), along with nine known alkaloids (
4 –
12 ), were isolated from the fruits of
Flueggea virosa (Roxb. ex Willd.) Voigt. Compounds
1 and
2 are two new fused tricyclic indole alkaloids possessing an unusual pyrido1, 2-aindole framework, and
3 presents a rare spiro (pyrrolizidinyl-oxindole) backbone. Their structures with absolute configurations were elucidated by means of comprehensive spectroscopic analysis, chemical calculation, as well as
X-ray crystallography. Chiral resolution and absolute configuration determination of the known compounds
4 ,
10 , and
11 were reported for the first time. The hypothetical biogenetical pathways of
1 –
3 were herein also proposed.
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