Abstract:
Three new isocoumarin derivatives, (
S)-6,8-dihydroxy-5-(methoxymethyl)-3,7-dimethylisochroman-1-one (
1 ), (
S)-6,8-dihydroxy-3,5,7-trimethyl-isochroman-1-one (
2 ) and (
R)-2-chloro-3-(8-hydroxy-6-methoxy-1-oxo-1
H-isochromen-3-yl) propyl acetate (
3 ), along with four known compounds (
4 –
7 ) were isolated from a mangrove endophytic fungus
Penicillium sp. YYSJ-3. Their structures were established on the basis of the extensive spectroscopic data and HR-ESI-MS analysis. The absolute configurations of
1 –
3 were further determined by
X-ray diffraction analysis and optical rotations. Compounds
3 ,
6 and
7 showed promising inhibitory activity against
α-glucosidase, which were stronger than that of the positive control 1-deoxynojirimycin (IC
50 141.2 μmol·L
−1).