Abstract: One new dimeric ( 1 ) and two monomeric sesquiterpene lactones ( 5 and 13 ), together with 10 known compounds ( 2 - 4 , 6 - 12 ), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC₅₀ values ranging from 2 to 25 μmol·L^-1.