Abstract:
Seven new isoquinoline alkaloids, 9-(2'-formyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (
1 ), 9-(2'-formyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (
2 ), 3-methoxy-2'-formyl oxohernandalin (
3 ), (-)-9-(2'-methoxycarbonyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (
4 ), (-)-2'-methoxycarbonyl thaliadin (
5 ), (-)-9-(2'-methoxyethyl-5', 6'-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (
6 ), (-)-3-methoxy hydroxyhernandalinol (
7 ), together with six known isoquinoline alkaloids (
8-13 ) were isolated from the roots of
Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic measurements. Compounds
1 and
2 showed significant selective cytotoxicity against glioma stem cells (GSC-3
# and GSC-18
#) with IC
50 values ranging from 2.36 to 5.37 μg·mL
-1.