Abstract:
The flower buds of
Lonicera macranthoides (Shan Yin-Hua), represent an important traditional Chinese medicine and food ingredient. A phytochemical investigation of the 70% EtOH extract of the flower buds of
L. macranthoides resulted in the isolation of 12 triterpenoids (
1-12 ), including two new ursane-type nortriterpenes, 2
α, 24-dihydroxy-23-nor-ursolic acid (
1 ) and 2
α, 4
α-dihydroxy-23-nor-ursolic acid (
2 ). Their structures were established by multiple spectroscopic methods and comparison with literature data. All isolated compounds were evaluated for their anti-inflammatory effects in LPS-activated RAW264.7 cells. Compounds
1 and
2 exhibited inhibitory effects on iNOS at the concentration of 30 μmol·L
-1.
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