Abstract:
Guided by TNF-
α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3
β, 30-diol (
1 ) and 22
α-hydroxy-20-taraxasten-30
β, 30-triol (
2 ), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant
Cirsium setosum. Their structures were elucidated by spectroscopic data and CD data analysis. In the TNF-
α secretion inhibitory activity assay, compounds
1 and
2 were active with the IC
50 of 2.6 and 3.8 μmol·L
-1, respectively. In addition, compounds
1 and
2 showed moderately selective cytotoxicity against the human ovarian cancer (A2780) and colon cancer (HCT-8) cell lines.
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