doi:10.1016/S1875-5364(18)30136-5

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Qiong ZHANG, Qing-Hong ZHENG, Yi-Shu SANG, Herman Ho-Yung SUNG, Zhi-Da MIN. New limonoids isolated from the bark of Melia toosendan[J]. Chinese Journal of Natural Medicines, 2018, 16(12): 946-950. DOI: 10.1016/S1875-5364(18)30136-5

Citation:

Qiong ZHANG, Qing-Hong ZHENG, Yi-Shu SANG, Herman Ho-Yung SUNG, Zhi-Da MIN. New limonoids isolated from the bark of Melia toosendan[J]. Chinese Journal of Natural Medicines, 2018, 16(12): 946-950. DOI: 10.1016/S1875-5364(18)30136-5

New limonoids isolated from the bark of Melia toosendan

摘要

Abstract: Two new limonoids, 12-ethoxynimbolinins G and H (compounds 1 and 2 ), and one known compound, toosendanin (Chuanliansu) (compound 3 ), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin ( 3 ) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.

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