Abstract:
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of
Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-
O-(5"-
O-galloyl)-
α-L-arabinofuranoside (
1 ), 6-methylquercetin 7-
O-β-D-glucopyranoside (
2 ), one new methylchromone glycoside, 7-
O-(4', 6'-digalloyl)-
β-D-glucopyranosyl-5-hydroxy-2-methylchromone (
3 ), together with three known compounds (
4 -
6 ). The structures of these isolated compounds were established on the basis of 1D and 2D NMR techniques and chemical methods. The anti-inflammatory activities of the compounds
1 -
6 were evaluated for their inhibitory effects against cyclooxygenases-1 and -2
in vitro. Compounds
1 -
6 showed potent COX-1 and COX-2 inhibiting activities
in vitro with IC
50 values ranging from 1.95 to 5.54 μmol·L
-1 and ranging from 1.01 to 2.27 μmol·L
-1, respectively.