Abstract:
The present study was designed to further investigate the C
21 steroidal glycosides in
Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (
1 ) and komaroside Q (
2 ), together with three known compounds (
3 -
5 ) were isolated from the whole herbs of
Cynanchum komarovii. The aglycones of compounds
1 and
2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (
1 -
5 ) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC
50 values ranging from 16.6 to 26.3 μmol·L
-1, compared to the positive control 5-fluorouracil (6.4 μmol·L
-1).
下载: