Abstract:
Two new sesquiterpenes, trivially named ricinusoids A (
1 ) and ricinusoids B (
2 ), were isolated from ethyl acetate fraction of
Ricinus communis. The structures of new compounds were elucidated by detailed spectroscopic techniques, including 1D-and 2D-NMR, UV, IR spectroscopy, and mass spectrometry. The compounds (
1 −
2 ) were also assessed for
in-
vivo sedative and analgesic like effects in open field and acetic acid induced writhing tests respectively at 5, 10, and 20 mg·kg
−1 i.p. Pretreatment of both test compounds caused significant (
P ≤ 0.05) reduction in locomotive activity like sedative agents and abdominal constrictions like analgesics. Both compounds (
1 −
2 ) possessed marked sedative and antinociceptive effects in animal models.
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