A new Lycopodium alkaloid from Phlegmariurus fargesii

AIM:To investigate the chemical constituents from the whole plants of Phlegmariurus fargesii.METHOD:Compounds were isolated by repeated silica gel column chromatography.Their structures were elucidated by spectroscopic methods and chemical correlation.The acetylcholinesterase(AChE) inhibitory activity of the isolated compounds was evaluated.RESULTS:A new Lycopodium alkaloid,lycopodine N-oxide(1),along with lycopodine(2),8,15-dehydrolycopodine(3),6-hydroxylycopodine(4),deacetyllycoclavine(5),N-methylhuperzine B(6),lycodine(7),and phlegmarine(8),was isolated.CONCLUSION:Compound 1 is a new Lycopodium alkaloid,and compound 3 was obtained from nature for the first time.Other alkaloids are isolated from this plant for the first time.